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A major issue with depression treatments seems to be a lack of conclusive 'mechanism of action'. This makes it difficult to choose between the different treatments, since they are acting on physiological conditions in a slightly uncertain way (where there are often no measurable physiological targets in mind, other than for the patient to 'feel' better).

UNITED STATES / OCT 21, 2014 1:52 PM EST

in response to: Has anyone read a good, summary analysis of all potential treatments for depression?
I'm right here. I didn't realize you missed me so much. That makes me feel really good.

UNITED STATES / OCT 21, 2014 8:49 AM EST

in response to: How come you don't come to JC anymore? I miss you
Hurt your feelings.

UNITED STATES / OCT 21, 2014 8:03 AM EST

in response to: Do you easily forgive someone?
I know the feeling.

UNITED STATES / OCT 17, 2014 9:01 PM EST

in response to: Have you ever had a meaningful conversation with a flower?
In the bathtub, slit your wrists with a razor under warm water, you'll bleed out and won't feel a thing

UNITED STATES / OCT 17, 2014 6:02 PM EST

in response to: I'm 12 years old I'm suicidal. Now, before you go on thinking I'm an attention seeking whore, I'm not. I just want to know, what are quick and easy ways to kill yourself without pain? Thanks
i wasn't on here for maybe 7 years. i never see italy on here now. rarely Neth. i feel like i am maybe missing something?..i don't recall either of them posting the same things over like you describe. i remember them being funny and witty. should i be taking the posts made by strangers more seriously or personally? i have no reason to think of someone i've never met as a cunt.

SOUTH AFRICA / OCT 17, 2014 12:57 PM EST

in response to: Who is a bigger cunt, Suzy "Neth" or Steve "Italy"?
A feeling of superiority and to hurt others feelings.

UNITED STATES / OCT 17, 2014 11:11 AM EST

in response to: Why do people always judge other people?
the guy is turned on by kids because he has those feelings in him as do most guys who call themselves normal no normal male would have a problem with pedos UNLESS they are denying their own desire for kids. the ones that are fighting against pedophilia are the very ones that are fighting their own pedophilia real normal men wouldn't have a problem with pedophiles because they wouldn't care. why? no emotions connected to the act.

UNITED STATES / OCT 16, 2014 12:35 PM EST

in response to: Advertisement: Would you like to go on a Strange Adventures(R) Tour? from Dirty Donkey Prod. with Gay Hat Enterprises. Contact proprietor: Mr. N. Slape, Gaily Faggot Buming and Slonder Systems, P.O. Box 261, Gillingham, Kent., U.K.
the guy is turned on by dick because he has those feelings in him as do most guys who call themselves straight no straight male would have a problem with homos UNLESS they are denying their own desire for dick. the ones that are fighting against homosexuality are the very ones that are fighting their own homosexuality real heterosexual men wouldn't have a problem with homosexuals because they wouldn't care. why? no emotions connected to the act.

UNITED STATES / OCT 16, 2014 12:30 PM EST

in response to: Advertisement: Would you like to go on a Strange Adventures(R) Tour? from Dirty Donkey Prod. with Gay Hat Enterprises. Contact proprietor: Mr. N. Slape, Gaily Faggot Buming and Slonder Systems, P.O. Box 261, Gillingham, Kent., U.K.
No feel.

UNITED STATES / OCT 14, 2014 9:15 PM EST

in response to: Anyone feel?
Typical fall weather here too. I actually like it. I like how peaceful it can sometimes feel.

UNITED STATES / OCT 13, 2014 4:57 PM EST

in response to: it is dark and windy here. i'd like to know what it's like where you are, and if you like it?
Tell the one you've been with for three years how you feel like your relationship is dying down. If it's not what you want go for the adventurous soul

UNITED STATES / OCT 11, 2014 3:59 PM EST

in response to: Do I say with the man I've been with for 3 years (relationship is stale lately). Or do I go with a man I've met that has an adventurous soul.
Yes, somedays people act differently because they feel younger. It's about your view on yourself and how you view your actual age

UNITED STATES / OCT 11, 2014 3:55 PM EST

in response to: People say that youth is a state of mind, do you agree?
I really don't feel sorry for you.

UNITED STATES / OCT 11, 2014 9:00 AM EST

in response to: OK, It's apparent that the person who answers questions with 'mehxt' is bored with the question. I'm OK with them being bored, cos, quite frankly I'm bored with them. However pointing out that they're boring as hell to try and get them to stop answering 'mehxt' works as well as them posting that answer to stop people from posting the questions they find boring. So my question is this; what exciting questions can we ask to keep the 'mehxt' answer at bay?
No need to feel sorry for me. I accepted the reality of things many years ago. Death is natural. When my wife left to visit with her sister this morning, I knew there was a chance something would happen to her while she was gone and I'd never see her again. Same with the kids. At the end of the day, shit happens. Knowing that makes one appreciate things in a new light.

UNITED STATES / OCT 11, 2014 8:53 AM EST

in response to: OK, It's apparent that the person who answers questions with 'mehxt' is bored with the question. I'm OK with them being bored, cos, quite frankly I'm bored with them. However pointing out that they're boring as hell to try and get them to stop answering 'mehxt' works as well as them posting that answer to stop people from posting the questions they find boring. So my question is this; what exciting questions can we ask to keep the 'mehxt' answer at bay?
If you consider your life a terminal illness, I feel sorry for you.

UNITED STATES / OCT 11, 2014 8:44 AM EST

in response to: OK, It's apparent that the person who answers questions with 'mehxt' is bored with the question. I'm OK with them being bored, cos, quite frankly I'm bored with them. However pointing out that they're boring as hell to try and get them to stop answering 'mehxt' works as well as them posting that answer to stop people from posting the questions they find boring. So my question is this; what exciting questions can we ask to keep the 'mehxt' answer at bay?
I would miss him if he went away but it would be such a good feeling to be able to miss him.

UNITED STATES / OCT 10, 2014 5:42 PM EST

in response to: "ITALIAN BISHOPS CALL FOR FAITHFULLY TO PREY FOR SISTERS' CUNTS STUFFED WITH CAT SHlT" (Yeah, "Fućk the rest," says god) ITALY/Aug 14, 2014 09:40 AM
how does it feel knowing you can buy the same crap at walmart for 5 bucks

UNITED STATES / OCT 6, 2014 10:05 PM EST

in response to: I ordered the nicest lil, girly things online. I can't wait till they come. :)
Is he a disgruntled native American who feels the entire world owes him a living, by any chance?

UNITED STATES / OCT 6, 2014 1:37 PM EST

in response to: I love my boyfriend and don't want to leave, but how can I make him see what a monster he is?
what you're worried about doesn't really matter. You might die this afternoon. Just do something nice for somebody else, you'll feel a lot better.

UNITED STATES / OCT 5, 2014 12:40 PM EST

in response to: How about some motivation?
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